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Cell motility is a fascinating example of cell behavior which is fundamentally important to a number of biological and pathological processes. It is based on a complex self-organized mechano-chemical machine consisting of cytoskeletal filaments and molecular motors. This network is highly dynamic, but able to show precise spatial and temporal organization. The machine is regulated by a complex network of biochemical reactions coupled to force and movement generating processes.

In general, the cytoskeleton is responsible for the movement of the entire cell and for movements within the cell. There are two ways by which cells can move: swimming (i.e. movement through liquid water) and crawling (i.e. movement across a rigid surface). Swimming cells experience viscous forces that are orders of magnitude greater than inertial forces. Therefore, swimming cells undergo an non-symmetric (i.e. non-reciprocal) sequence of shape changes. While for many bacterial cells motion is caused by the rotation of flagella, most swimming eukaryotic cells use the beating of hairlike extensions (such as cilia) to propel themselves through the liquid.

Of biological importance are not only the movements of the cell as whole but also movements within the cell boundaries. For example, during mitosis the replicated chromosomes are cleaved and pulled to opposite poles of the cell by the mitotic spindle. Not only chromosomes, but also many other large molecules must be moved to specific locations within the cell. This can be achieved with active transport by molecular motors which move along cytoskeletal filaments. This motion is much more precise and quicker than diffusional motion. Motor proteins are essential for many processes of cellular motion. There is a whole variety of different motors. The most important classes include: linear motors (such as myosin, kinesin and dynein), rotatory motors (such as ATP synthase and bacterial flagella), and nucleic acid motors (such as helicases and topoisomerases). The linear motors use ATP to move along filaments. But they are much more than simple transporters. Two headed motors attach to adjacent filaments leading to sliding of oppositely oriented filaments (which is responsible for, e.g., muscle contraction). These induced interactions give rise to a complex cooperative behavior of collections of motors allowing cells to actively deform their shape.

On the other hand, single motors can exhibit more complex shape changes. For example, ATPsynthase (the motor which produces ATP) performs a rotational motion. While the biological function of the fluid flow generated by this motor is so far not understood, other rotatory motors enable bacteria to swim. For example, the flagellum of E.coli uses an ion flux to drive its rotation.

Superior: Journeys on an Inland Sea is the story of the McGuffins' incredible 80-day, 2,000-mile circumnavigation of Lake Superior, the largest expanse of fresh water on Earth. It is a story of spirited adventure and physical triumphs, of breathtaking natural beauty and environmental sensibility. This book conveys the vastness and mystery of the lake and its shores like no other.

John Leland lived a Huckleberry Finn sort of boyhood that most children would envy. A fifth-generation lowcountry native, he grew up fishing, swimming, and hunting arrowheads on a tidal creek just north of Charleston, South Carolina. With admirable freedom, he poled his bateau through the maze of oyster banks and the tangle of salt waterways known as Porcher's Creek. He spent years learning where the conchs congregated, where the clams kept secret rendezvous, and which hole hid the sweetest crabs. He became a naturalist by studying heron, frogs, and porpoises. Leland's existence was so intertwined with Porcher's Creek that he lived, slept, and ate by its tides and seasons--until exiled by family misfortune and suburban encroachment.

Leland combines nature writing and reminiscence with a heartfelt examination of change along the South Carolina coast. He celebrates Porcher's Creek as a watery refuge that links him to his childhood and ancestry, weaving together his family's story with that of the creek. He chronicles both the geographic dispersal of his family and the abandonment of traditional lowcountry ways of life.